XELJANZ^® XR

What is XELJANZ^® XR?

• XELJANZ^® XR is the extended release version of XELJANZ^®9
• It is a tablet with a semipermeable membrane and delivery port¹⁰
• The delivery port allows a controlled release of the active ingredient¹⁰​
• Provides a once-daily dosing alternative¹⁰

1. XELJANZ^® XR consists of a core surrounded by a semipermeable membrane¹⁰
2. As water enters the system, the pressure builds up and pushes the active ingredient out of the delivery port¹¹
3. Components are released through the delivery port over time¹¹

• The active ingredient’s daily maximum and average concentration in your body is similar for both XELJANZ^® and XELJANZ^® XR¹⁰

How to take XELJANZ^® XR?⁹

• XELJANZ^® XR may be used alone or in combination with methotrexate or other non-biological therapies
• The recommended dose of XELJANZ^® XR is 11mg once daily
• XELJANZ^® XR should be taken orally, with or without food
  Swallow XELJANZ^® XR tablets whole and intact. Do not crush, split, or chew
• When you take XELJANZ^® XR, you may see something in your stool that looks like a tablet. This is the empty shell from the tablet after the medicine has been absorbed by your body